Cylindrospermopsin

Trivial Names: Cylindrospermopsin
Source Organism: Cylindrospermopsis raciborskii
CAS Registry Number: 143545-90-8
Formula: C15H21N5O7S
Exact Mass: 415.12
Formula Weight: 415.12
Production Method: Natural product
Storage/Shipping Conditions: This material is packaged in glass vials and is shipped with an ice pack. If prolonged storage is required, keep in a tightly sealed container at -20C
Toxicity: Toxic

Mode of action: Cylindospermopsin is a water-soluble tricyclic hepatotoxic alkaloid isolated from cyanobacteria such as Cylindospermopsis raciborskii 1. High concentrations of the organism and toxin have been identified in drinking water reservoirs and natural lakes during warmer periods in the USA and Australia². Cylindospermopsin inhibits protein synthesis, is potentially carcinogenic and inhibits pyrimidine nucleotide synthesis ^3,4.

1. I Ohtani, et al, JACS 1992, 114, 7941
2. I. R. Falconer and A. R. Hompage, Environ. Toxicol., 2006, 21, 299-304
3. I. R. Falconer and A. R. Hompage, Environ. Toxicol., 2001, 16, 192-1954. G. R. Shaw, et al, Ther. Drug. Monit., 2000, 22, 89-92
4. G. R. Shaw, et al, Ther. Drug. Monit., 2000, 22, 89-92