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PbTx-3
Trivial Name: PbTx-3
CAS Registry Number: 85079-48-7
Source Organism:Karenia brevis
Formula: C50H72O14
Exact Mass: 896.4914
Formula Weight: 897.2
Production Method: Semisynthetic derivative of natural product
Storage/Shipping Conditions: Material is packaged in glass vials under vacuum and is stable
during shipment and under normal handling procedures. If prolonged storage is required, keep
the material in a tightly closed container at -20oC until needed
Mode of action:
Brevetoxins are known to bind to site 5 of voltage-gated sodium channels in nerve cells, leading to channel activation. This leads to disruption of normal neurological processes and causes the illness clinically described as neurotoxic shellfish poisoning (NSP).1 PbTx-3 contains a brevetoxin B backbone.
Unit size: 5mg - $5870
1 (a) Edwards, R. A. et al. Mol. Brain Res. (1992) 14, 64-70; (b) Trainer, V. L. et al. Mol. Pharmacol. (1991) 40, 988-994; (c) Tsai, M. C., and Chen, M. L. Br. J. Pharmacol. (1991) 103, 1126-1128; (d) Trainer, V. L. et al. ACS Symposium Series (1990) 418, 166; (e) Baden, D. G. FASEB J. (1989) 3, 1807-1817; (f) Baden, D. G. et al. Toxicon (1988) 26, 97-103; (g) Poli, M. A. et al. Mol. Pharmacol. (1986) 30, 129-135; (h) Shimizu, Y. et al. J. Am. Chem. Soc. (1986) 108, 514-515; (i) Nakanishi, K. Toxicon (1985) 23, 473-479; (j) Baden, D. G. et al. Toxicon (1982) 19, 455-462; (k) Catterfall, W. A. , and Risk, M. Mol. Pharmacol. (1981) 19, 345-348.