Okadaol

Trivial Name:okadaol
CAS Registry Number: 131959-12-1
Source Organism:Prorocentrum lima
Formula: C44H70O12
Exact Mass: 790.4859
Formula Weight: 791.1
Production Method: Semisynthetic derivative of natural product
Storage/Shipping Conditions: -20^oC

Mode of action:
Okadaic acid is a polyether from the dinoflagellate Prorocentrum lima that is the causative agent of diarrhetic shellfish poisoning (DSP).¹ Okadaic acid acts as a non-phorbol ester type tumor promoter² and as an inhibitor of protein phosphatases PP1 and PP2A.³ Okadaol is derived from okadaic acid by reduction of the carboxyl group and is inactive against protein phosphatases.⁴

1 Yasumoto, T. et al. Tetrahedron (1985) 41, 1019-1025. 2 Suganuma, M. et al. Proc. Nat. Acad. Sci. USA (1988) 85, 1768-1771. 3 (a) Takai, A. et al. FEBS Lett. (1987) 217, 81-84; (b) Haystead, T. A. et al. Nature (1989) 337, 78-81. 4 Nishiwaki, S. et al. Carcinogenesis (1990) 11, 1837-1841.