PbTx-1

Trivial Name: PbTx-1
CAS Registry Number: 98112-41-5
Source Organism: Karenia brevis
Formula: C49H70O13
Exact Mass: 866.4808
Formula Weight: 867.2
Production Method: Natural product
Storage/Shipping Conditions:  Material is packaged in glass vials under vacuum and is stable during shipment and under normal handling procedures. If prolonged storage is required, keep the material in a tightly closed container at -20°C until needed.

Mode of action:
Brevetoxins are known to bind to site 5 of voltage-gated sodium channels in nerve cells, leading to channel activation. This leads to disruption of normal neurological processes and causes the illness clinically described as neurotoxic shellfish poisoning (NSP).1 PbTx-1 contains a brevetoxin A backbone.

1 (a) Edwards, R. A. et al. Mol. Brain Res. (1992) 14, 64–70; (b) Trainer, V. L. et al. Mol. Pharmacol. (1991) 40, 988–994; (c) Tsai, M.C., and Chen, M. L. Br. J. Pharmacol. (1991) 103, 1126–1128; (d) Trainer, V. L. et al. ACS Symposium Series (1990) 418, 166; (e) Baden, D. G. FASEB J. (1989) 3, 1807–1817; (f) Baden, D. G. et al. Toxicon (1988) 26, 97–103; (g) Poli, M. A. et al. Mol. Pharmacol. (1986) 30, 129–135; (h) Shimizu, Y. et al. J. Am. Chem. Soc. (1986) 108, 514–515; (i) Nakanishi, K. Toxicon (1985) 23, 473–479; (j) Baden, D. G. et al. Toxicon (1982) 19, 455–462; (k) Catterfall, W. A. , and Risk, M. Mol. Pharmacol. (1981) 19, 345–348.