MARBIONC ELISA Kits are now available through SeaTox Research and can be purchased following the link here or reaching out to UNCW for a direct referral.
Trivial Name: PbTx-1
CAS Registry Number: 98112-41-5
Source Organism: Karenia brevis
Formula: C49H70O13
Exact Mass: 866.4808
Formula Weight: 867.2
Production Method: Natural product
Storage/Shipping Conditions: Material is packaged in glass vials under vacuum and is stable during shipment and under normal handling procedures. If prolonged storage is required, keep the material in a tightly closed container at -20°C until needed.
Mode of action:
Brevetoxins are known to bind to site 5 of voltage-gated sodium channels in nerve cells, leading to channel activation. This leads to disruption of normal neurological processes and causes the illness clinically described as neurotoxic shellfish poisoning (NSP).1 PbTx-1 contains a brevetoxin A backbone.