[D-Asp3, (E)-Dhb7] Microcystin-HphR Place Order

MARBIONC ELISA Kits are now available through SeaTox Research and can be purchased following the link here or reaching out to UNCW for a direct referral.

[D-Asp3, (E)-Dhb7] Microcystin-HphR

Trivial Name : [D-Asp3, (E)-Dhb7]Microcystin-HphR

CAS Registry Number: 1430108-50-1
Source Organism: Microcystis aeruginosa
Formula: C 52 H 72 N 10 O 12
Exact Mass: 1028.53
Formula Weight: 1029.19
Production Method: Natural product
Storage/Shipping Conditions: This material is packaged in glass vials and is shipped with an ice pack. If prolonged storage is required, keep in a tightly sealed container at -20oC

Toxicity : Toxic; Hepatotoxin; and Possible carcinogen

Mode of action:
Microcystins are cyclic hybrid non-ribosomal peptide toxins isolated from various cyanobacteria.1 Microcystins inhibit eukaryotic protein phosphatases PP1 and PP2a and are selectively transported to the liver resulting in acute liver failure and tumor promotion.2

Unit size: 25 µg - $ 440

1 (a) Carmichael, W. W. et al. Toxicon (1988) 26, 971-973; (b) Rinehart, K. L. et al. J. Am. Chem. Soc. (1988) 110, 8557-8558. 

2 (a) MacKintosh, C. et al. FEBS Lett. (1990) 264, 187-192; (b) Chorus, I. et al. J. Toxicol. Env. Health B
(2000) 3, 323-347; (c) Zurawell, R. et al. J. Toxicol. Env. Health B (2005)8, 1-37.